Reviewing the Architecture -> "Zoom" matters We examined the architecture of leading foundation models, specifically Virchow, alongside NatImg, PLIP, CTransPath, and Phikon. A critical constraint emerged regarding image resolution because these models were predominantly trained on 20× patches (approximately 0.5 µm/pixel). This establishes a strict preference for native resolution. While humans adapt easily between magnifications, these models are highly sensitive to pixel density. Feeding t...

Clip source: https://alexw.substack.com/p/hire The second (giving a shit about work in general) is equally important. It’s possible to fake fervor in the course of an interview and say the right things to convince us of enthusiasm for Scale, but the proof is in the pudding. If someone is applying to Scale and has never been deeply obsessed about something before, then it’s a bad bet to think Scale will be the first. I have a particular line of questioning around this: What’s the hardest you’v...