Along with Psalm 22, this Psalm is the most frequently quoted in the New Testament. The humiliation and rejection of Jesus are clearly seen. Verses 14-20 describe His Gethsemane experience and verse 21 prophesies an event which occurred during His crucifixion.
The Psalmist is rejected and alienated because of his righteous zeal for God's Kingdom. He has spoken against sin and pleaded for revival among God's people. For this he suffers at the hands of those who were comfortable with the spiritual status quo.