รอบ 1

ที่จำไม่ได้ล่ะกัน

  • PK causing decreased drug effects
    • Drug binding in the gut: kaloin-pectin suspensions, aluminum-contaning antacids, bile acid sequestrants.
    • alter gastric pH decreased the soluability and hense absorption of weak base such as ketoconazole
    • expression of some genes resiponsible for drug elimination notable CYP3A4, ABCB1, can be markly incresed by inducing drugs
      • inducing drugs: glutethimide, nevirapine
      • smoking, chronic alcohol ingestion, exposure to chlorinated insectiside
    • Interaction with drug delivery to intracellular cell site of action
    • tricyclic antidepressants can blunt of clonidine by decreasing its uptake into adrenergic
    • reduced CNS penetration of multiple HIV protease inhibitors appear attributable from P-glycoprotein-mediated exclusion from CNS, indeed inhibition of  P-glycoprotein has been purpose as a therapeutic appraoch to enhance drug entry into CNS


You'll only receive email when Panu publishes a new post

More from Panu: